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Lymphosarcoma PDF Print E-mail

Clinical Signs:

  • Enlarged lymph nodes.
  • Vomiting, diarrhea, or loss of appetite (if gastro-intestinal).

Possible causes:

  • Breed related (Labrador retrievers, golden retrievers, boxers, cocker spaniels)
  • Associated with exposure to Chemlawn (risk factor) for dogs.

Clinical stages for Dogs:

I - Involvement limited to a single node or lymphoid tissue in a single organ.

II - Regional involvement of many lymph nodes, with or without involvement of the tonsils.

III - Generalized lymph node involvement.

IV - Involvement of liver and/or spleen, with or without generalized lymph node involvement.

V - Involvement of blood, bone marrow, central nervous system, eye and/or other organs.


High calcium seen in 10-15% of dogs, most commonly associated with mediastinal mass and can also cause renal disease.

  • Bone marrow aspirate.
  • Fine needle aspirate of lymph nodes and other affected organs.
  • Dog lymphosarcoma is mostly multicentric.

Treatment and prognosis:

 2 - month median survival with prednisone therapy alone.

 6 - month median survival with single chemotherapy agent and prednisone.

 12 - month median survival with combination chemotherapy.

 First line agents: elspar, prednisone, vincristine, adriamycin, chlorambucil, cytoxan

 Most dogs will relapse by the end of the first year.

 75% will go into remission the first time.

 35% will go into remission at rescue.



 Cause: FeLV in young cats. Older cats may have been FeLV +. 70% of cats with lymphosarcoma are FeLV+.

  • Usually intestinal or mediastinal.
  • Don't usually have enlarged lymph nodes.