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  • Primary disease from autoimmune destruction of the thyroid gland -- thyroid gland atrophy.
  • Lack of thyroid hormone production by destroyed thyroid cells.


 

SIGNALMENT

  •  Young-adult to middle aged dogs (2 - 9 years).
  • Dobermans, boxers, golden retrievers, and labs (large breed dogs).

CLINICAL SIGNS

Weight gain, decreased appetite, lethargy, dermatologic signs (seborrhea, bilateral symmetrical alopecia, hyperpigmentation, rat-tail, otits externa), weakness, laryngeal paralysis, reproductive problems (infertility in female), megaesophagus, seizures, neurologic signs.

 

CLINICOPATHOLOGIC ABNORMALITIES

  •   Non-regenerative anemia, fasting hypercholesterolemia, hypertriglyceridemia.


 

DIAGNOSIS

  • Measuring total T4, free T4, and TSH - Michigan State panel.
  • Decrease in T4, but increase in TSH.
  • Sick euthyroid - see decrease TSH.

TREATMENT

  •  Soloxine -- thyroid hormone supplementation (T4).
  • Monitor T4 and TSH levels on thyroid replacement medication